5-Amino-1MQ

Overview

5-Amino-1MQ is a small molecule, not a peptide — it has no amino-acid sequence and is a membrane-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). By inhibiting NNMT, it is proposed to shift cellular metabolism (raising NAD+ and SAM in fat cells) and increase adipocyte energy expenditure. All of the supporting evidence is preclinical: in diet-induced obese mice, NNMT inhibition reduced body weight and fat mass without changing food intake. There are no published human clinical trials, and it is not FDA-approved. Any human benefit claims are extrapolated from animal data and should be treated as unproven.

Commonly Reported Uses

These are uses commonly discussed or marketed by users and vendors — not a list of proven or approved benefits, and not a recommendation.

• Fat loss / body-composition change (marketed claim; preclinical/animal data only, no human trials)
• Increased metabolic rate / energy expenditure (marketed claim; mechanism shown in mice, not humans)
• Anti-aging / NAD+ support (marketed claim; no controlled human evidence)

What to Track

Data points you and your clinician might monitor. For observation only — not a diagnostic protocol.

• Smart scale — weight and body-fat % trend over a defined baseline
• InBody/DEXA — skeletal muscle mass and body-fat % changes
• Subjective — daily energy and appetite check-ins
• Labs — lipid panel and fasting glucose if a clinician is monitoring metabolic markers
• MyFitnessPal — calories and protein g/kg, to separate diet effects from the compound

Sources & References

1. [1]Selective and membrane-permeable small molecule inhibitors of NNMT reverse high fat diet-induced obesity in mice — PMC
2. [2]5-Amino-1MQ: An NNMT Inhibitor — overview