Dihexa

Overview

Dihexa is a synthetic peptide derived from angiotensin IV, engineered to cross the blood-brain barrier and promote the formation of new synapses. In cell and rodent studies it has shown potent procognitive and synaptogenic effects that appear to depend on activation of the hepatocyte growth factor (HGF)/c-Met system. Despite striking laboratory potency, the published evidence is essentially entirely preclinical — there are no adequate controlled human efficacy trials and it is NOT FDA-approved. Any human cognitive benefit is unproven, and the marketing comparisons to BDNF refer to in-vitro potency, not demonstrated clinical effect.

Commonly Reported Uses

These are uses commonly discussed or marketed by users and vendors — not a list of proven or approved benefits, and not a recommendation.

• Cognitive enhancement / memory (marketed claim; no controlled human efficacy data)
• Neurorepair / support in neurodegeneration (preclinical concept only; not demonstrated in humans)

What to Track

Data points you and your clinician might monitor. For observation only — not a diagnostic protocol.

• Subjective — daily cognition, memory, and focus check-ins over a baseline period
• WHOOP — sleep stages and HRV trend as general neuro/recovery context
• Subjective — mood and anxiety check-ins to monitor tolerability

Sources & References

1. [1]The Procognitive and Synaptogenic Effects of Angiotensin IV–Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System — PMC